Rabbit Secondary Antibodies
ABclonal Technology CYP24A1 Rabbit mAb
This gene encodes a member of the cytochrome P450 superfamily of enzymes The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol steroids and other lipids This mitochondrial protein initiates the degradation of 1 25-dihydroxyvitamin D3 the physiologically active form of vitamin D3 by hydroxylation of the side chain In regulating the level of vitamin D3 this enzyme plays a role in calcium homeostasis and the vitamin D endocrine system Alternatively spliced transcript variants encoding different isoforms have been found for this gene
Cayman Chemical HIston H4CTerm RabbIt Mo 100ug
Immunogen: Peptide corresponding to the C-terminus of human histone H4 • Host: Rabbit • Species Reactivity: (+) Vertebrates • Cross Reactivity: (+) H4A independent of PTMs; (-) Other histone proteins • Applications: ELISA, ICC, multiplex-based assays, WB
ABclonal Technology KPNB1 Rabbit mAb
Nucleocytoplasmic transport which requires energy and signals occurs through nuclear pore complexes in the nuclear envelope Import of proteins with a nuclear localization signal (NLS) involves the NLS import receptor a heterodimer of importin alpha and beta subunits (karyopherins) Importin alpha binds the NLS cargo in the cytoplasm and importin beta docks the complex at the nuclear pore With nucleoside triphosphates and Ran GTPase the complex enters the pore dissociating into importin alpha and beta Importin alpha carries the cargo into the nucleoplasm while importin beta stays at the pore Importin beta interacts with FG repeats of nucleoporins to aid translocation This gene encodes a member of the importin beta family with two splice variants encoding different isoforms
ABclonal Technology RAB8A Rabbit mAb
This gene encodes a protein in the RAS superfamily a group of small GTP/GDP-binding proteins ( 200 amino acids) involved in intracellular signaling RAB/YPT family members including this protein may help transport proteins from the endoplasmic reticulum to the Golgi and plasma membrane The protein shares high sequence similarity with dog RAB8 (97%) and mouse MEL (96%) and contains the four conserved GTP/GDP-binding sites typical of RAS proteins It also has a C-terminal CAAX motif common in RAS proteins but absent in most RAB/YPT proteins Although originally identified as a transforming gene from a melanoma cell line no clear link between this gene (MEL) and malignant melanoma has been established It is located about 800 kb downstream of MY09B on chromosome 19p13 1
ABclonal Technology GSTA4 Rabbit mAb
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families These enzymes are involved in cellular defense against toxic carcinogenic and pharmacologically active electrophilic compounds At present eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified alpha kappa mu omega pi sigma theta and zeta This gene encodes a glutathione S-tranferase belonging to the alpha class The alpha class genes which are located in a cluster on chromosome 6 are highly related and encode enzymes with glutathione peroxidase activity that function in the detoxification of lipid peroxidation products Reactive electrophiles produced by oxidative metabolism have been linked to a number of degenerative diseases including Parkinson s disease Alzheimer s disease cataract formation and atherosclerosis
ABclonal Technology ASCL4 Rabbit mAb
Basic helix-loop-helix transcription factors such as ASCL4 are essential for the determination of cell fate and the development and differentiation of numerous tissues (Jonsson et al 2004 [PubMed 15475265])
ABclonal Technology HEXIM1 Rabbit mAb
Expression of this gene is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells This gene has no introns
ABclonal Technology PPCS Rabbit mAb
Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes PPCS (EC 6 3 2 5) one of the last enzymes in this pathway converts phosphopantothenate to phosphopantothenoylcysteine (Daugherty et al 2002 [PubMed 11923312])
ABclonal Technology CECR5 Rabbit mAb
Predicted to be involved in glycerophospholipid biosynthetic process Predicted to be active in mitochondrion
ABclonal Technology P Glycoprotein Rabbit mAb
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters ABC proteins transport various molecules across extra- and intra-cellular membranes ABC genes are divided into seven distinct subfamilies (ABC1 MDR TAP MRP ALD OABP GCN20 White) This protein is a member of the MDR TAP subfamily Members of the MDR TAP subfamily are involved in multidrug resistance The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs This protein also functions as a transporter in the blood-brain barrier Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13 Alternative splicing and the use of alternative promoters results in multiple transcript variants
ABclonal Technology IL1 Rabbit mAb
The protein encoded by this gene is a member of the interleukin 1 cytokine family This cytokine is produced by activated macrophages as a proprotein which is proteolytically processed to its active form by caspase 1 The encoded protein plays a role in thymocyte proliferation and is involved in the inflammatory response
ABclonal Technology Orexin B Rabbit mAb
This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides orexin A and orexin B by proteolytic processing Orexin A and orexin B which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2 function in the regulation of sleep and arousal This neuropeptide arrangement may also play a role in feeding behavior metabolism and homeostasis
ABclonal Technology MYO19 Rabbit mAb
Enables actin binding activity Involved in regulation of cytokinesis and regulation of mitochondrial fission Acts upstream of or within mitochondrion migration along actin filament Located in cytosol and mitochondrial outer membrane
ABclonal Technology GAS2 Rabbit mAb
The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity Alternative splicing results in multiple transcript variants
ABclonal Technology UCHL5IP Rabbit mAb
This gene encodes a subunit of the augmin complex which regulates centrosome and mitotic spindle integrity and is necessary for the completion of cytokinesis The encoded protein was identified by interaction with ubiquitin C-terminal hydrolase 37 Alternative splicing results in multiple transcript variants